GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs983392 | 1 | rs4939314 | chr11:59900575 | MS4A14 | chr11:60145958-60185226:+ | 0.17 | 4.38 | 1.46E-5 | Alzheimer's disease (late onset) |
| THCA | cis | rs494003 | 1 | rs494003 | chr11:65542298 | CTSW | chr11:65647284-65651212:+ | -0.23 | -4.76 | 2.59E-6 | Systemic lupus erythematosus |
| THCA | cis | rs494003 | 1 | rs494003 | chr11:65542298 | RNASEH2C | chr11:65485146-65488409:- | -0.18 | -4.53 | 7.34E-6 | Systemic lupus erythematosus |
| THCA | cis | rs494003 | 1 | rs494003 | chr11:65542298 | SNX32 | chr11:65601410-65621170:+ | 0.39 | 5.22 | 2.71E-7 | Systemic lupus erythematosus |
| THCA | cis | rs7116495 | 1 | rs4943821 | chr11:71813747 | FAM86C | chr11:71498557-71512276:+ | -0.32 | -4.06 | 5.81E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7107174 | 1 | rs4944195 | chr11:78003499 | NARS2 | chr11:78147017-78285909:- | -0.36 | -6.41 | 3.42E-10 | Testicular germ cell tumor |
| THCA | cis | rs7107174 | 1 | rs4944198 | chr11:78032605 | NARS2 | chr11:78147017-78285909:- | -0.39 | -7.04 | 6.66E-12 | Testicular germ cell tumor |
| THCA | cis | rs7116495 | 1 | rs4944232 | chr11:71642258 | FAM86C | chr11:71498557-71512276:+ | -0.34 | -4.28 | 2.28E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7116495 | 1 | rs4944242 | chr11:71667141 | FAM86C | chr11:71498557-71512276:+ | 0.34 | 4.1 | 4.89E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7116495 | 1 | rs4944258 | chr11:71743393 | FAM86C | chr11:71498557-71512276:+ | 0.32 | 3.91 | 0.000107 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7107174 | 1 | rs4945261 | chr11:77990260 | NARS2 | chr11:78147017-78285909:- | 0.36 | 6.49 | 2.15E-10 | Testicular germ cell tumor |
| THCA | cis | rs7107174 | 1 | rs4945267 | chr11:78037933 | NARS2 | chr11:78147017-78285909:- | -0.39 | -6.92 | 1.48E-11 | Testicular germ cell tumor |
| THCA | cis | rs7107174 | 1 | rs4945268 | chr11:78037936 | NARS2 | chr11:78147017-78285909:- | -0.39 | -6.92 | 1.48E-11 | Testicular germ cell tumor |
| THCA | cis | rs7107174 | 1 | rs4945270 | chr11:78068216 | NARS2 | chr11:78147017-78285909:- | -0.39 | -7 | 8.63E-12 | Testicular germ cell tumor |
| THCA | cis | rs7107174 | 1 | rs4945274 | chr11:78109260 | NARS2 | chr11:78147017-78285909:- | -0.4 | -7.5 | 3.07E-13 | Testicular germ cell tumor |